This book highlights the critical challenges faced in total hip replacement (THR) procedures, particularly concerning the performance and longevity of acetabular components. Despite advancements in implant technology, issues such as improper orientation and material failure continue to result in complications, including dislocation and wear. Recognizing the need for more reliable solutions, this book explores the optimization of safe zone orientation and the development of composite materials, specifically focusing on metal-on-polymer (MoP) implants. By investigating these factors through numerical analysis, finite element analysis (FEA), and experimental studies, the book seeks to enhance implant performance, reduce failure rates, and ultimately improve patient outcomes in THR surgeries.